ABSTRACT
To evaluate the biochemical changes in patients analyzing pre and postoperative samples and to update the current clinical practices. PMRC Research Centre, LUMHS Jamshoro, Department of Urology, LUH, Jamshoro. Urolithiasis patients admitted at the department of urology, LUH Jamshoro were registered for this clinical based research study. A total of '25' patients were selected for open surgery procedure during carrying out this study in 2005. Out of which '20' were registered who were willing to participate and given written consent. A proforma with detail history and investigations related to the objectives of the study was filled in each case. The pre- and postoperative blood and urine samples were collected and analyzed. Results are given in detail from Table No.1 to Table No.06. The results of this study show that patients suffering from kidney stones were feeling stressful in the early morning [pre-operative] before shifting to the operation theatre for open surgery. Thinking of a surgery is itself a painful experience. However, on the next morning i.e. 1[st] postoperative day felt more comfortable and subsequently on 3[rd] and 5[th] postoperative day felt quite normal and ready to be discharged. Open surgery is required if other physical interventions such as shock-wave lithotripsy to breakup the stones is unsuccessful. However, extra corporeal shock-wave lithotripsy [ESWL] and [PCNL] modalities have solved the problems to the extent in the cases in which kidney stones can be broken easily. Attention should also he paid to the prevention of stone formation by counseling with the patients by adopting preventive measures